Pyridine carboxamides: Potent palm site inhibitors of HCV NS5B polymerase
Abstract
(figure presented) The use of Pd2dba3 with bulky, electron-rich ligands 1 or 2 and LiN(TMS)2 as the base for the coupling of amines with aryl halides containing hydroxyl, amide, or enolizable keto groups is described. This protocol expands the utility of palladium-catalyzed C-N bond formation by allowing for the use of aryl halides containing these functional groups, obviating the need for protecting group manipulations.
Publication Title
ACS Medicinal Chemistry Letters
Recommended Citation
Harris, M., Huang, X., & Buchwald, S. (2010). Pyridine carboxamides: Potent palm site inhibitors of HCV NS5B polymerase. ACS Medicinal Chemistry Letters, 1 (9), 466-471. https://doi.org/10.1021/ml100128h
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