Titanium coated with 2-decenoic analogs reduces bacterial and fungal biofilms

Authors

Xiaohua Huang, Merck & Co., Inc.
Cliff C. Cheng, Merck & Co., Inc.
Thierry O. Fischmann, Merck & Co., Inc.
José S. Duca, Merck & Co., Inc.
Xianshu Yang, Merck & Co., Inc.
Matthew Richards, Merck & Co., Inc.
Gerald W. Shipps, Merck & Co., Inc.

Abstract

A novel series of CHK1 inhibitors with a distinctive hinge binding mode, exemplified by 2-aryl-N-(2-(piperazin-1-yl)phenyl)thiazole-4-carboxamide, was discovered through high-throughput screening using the affinity selection-mass spectrometry (AS-MS)-based Automated Ligand Identification System (ALIS) platform. Structure-based ligand design and optimization led to significant improvements in potency to the single digit nanomolar range and hundred-fold selectivity against CDK2. © 2012 American Chemical Society.

Publication Title

Journal of applied microbiology

Recommended Citation

Huang, X., Cheng, C., Fischmann, T., Duca, J., Yang, X., Richards, M., & Shipps, G. (2023). Titanium coated with 2-decenoic analogs reduces bacterial and fungal biofilms. Journal of applied microbiology, 134 (8) https://doi.org/10.1093/jambio/lxad155