Titanium coated with 2-decenoic analogs reduces bacterial and fungal biofilms
Abstract
A novel series of CHK1 inhibitors with a distinctive hinge binding mode, exemplified by 2-aryl-N-(2-(piperazin-1-yl)phenyl)thiazole-4-carboxamide, was discovered through high-throughput screening using the affinity selection-mass spectrometry (AS-MS)-based Automated Ligand Identification System (ALIS) platform. Structure-based ligand design and optimization led to significant improvements in potency to the single digit nanomolar range and hundred-fold selectivity against CDK2. © 2012 American Chemical Society.
Publication Title
Journal of applied microbiology
Recommended Citation
Huang, X., Cheng, C., Fischmann, T., Duca, J., Yang, X., Richards, M., & Shipps, G. (2023). Titanium coated with 2-decenoic analogs reduces bacterial and fungal biofilms. Journal of applied microbiology, 134 (8) https://doi.org/10.1093/jambio/lxad155
