Involvement of colchicine binding site of tubulin in the polymerisation process
Abstract
Role of lysine residues in the colchicine binding site and in the assembly-disassembly process was examined. It was observed that at 4°C (pH 7.5-8, 8±1) lysine residues and the N-terminal methionine residue of tubulin were all buried within the molecule. Evidence indicates that ε{lunate}-amino groups of lysine residues of tubulin are shared by both the colchicine binding site and the polymerisation process. © 1983.
Publication Title
FEBS Letters
Recommended Citation
Dasgupta, D., Rajgopalan, R., & Gurnani, S. (1983). Involvement of colchicine binding site of tubulin in the polymerisation process. FEBS Letters, 152 (1), 101-104. https://doi.org/10.1016/0014-5793(83)80491-8
COinS
