Absence of the t(2;5) in Hodgkin's disease
Abstract
The cytogenetics of Hodgkin's disease (HD) is poorly understood. However, a t(2;5) is a common finding in CD30+ anaplastic large cell lymphoma (ALCL), a neoplasm thought by some to be closely related to HD. Recently, the t(2;5) has been cloned and found to represent fusion of the NPM gene with the ALK gene. Using Southern blot hybridization, one group has reported finding rearrangements of NPM in a proportion of cases of both ALCL and HD. In the current study, we used a highly sensitive reverse transcriptase-polymerase chain reaction methodology to analyze 34 cases of HD for the t(2;5). We were unable to find polymerase chain reaction evidence for the t(2;5) in any of the cases of HD, a result significantly different from our previous study of CD30+ non-Hodgkin's lymphomas (P < .02) including ALCL (P < .04), using identical methods. Our results do not support the hypothesis that the t(2;5) represents a common chromosomal abnormality for both HD and ALCL.
Publication Title
Blood
Recommended Citation
Weiss, L., Lopategui, J., Sun, L., Kamel, O., Koo, C., & Glackin, C. (1995). Absence of the t(2;5) in Hodgkin's disease. Blood, 85 (10), 2845-2847. https://doi.org/10.1182/blood.v85.10.2845.bloodjournal85102845
