CD5. A review

Abstract

Antibodies that detect the antigen defined by the cluster designation group 5 (CD5) were originally described as pan-T lymphocyte markers. They have subsequently been shown to immunoreact with a subset of circulating B lymphocytes and some cases of B-cell lymphoma and leukemia. Nonneoplastic CD5-positive B lymphocytes are increased in normal fetal cord blood as well as in the peripheral blood of adult patients with a variety of diseases, particularly autoimmune disorders. This review describes the expression of CD5 on hematopoietic cells as well as the expression of this antigen in various nonneoplastic and malignant disorders. The value of detection of the CD5 antigen in the diagnosis and classification of T-cell lymphomas and leukemias as well as in low-grade B-cell lymphomas is discussed.

Publication Title

Applied Immunohistochemistry

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