Follicular lymphoma with blastic conversion: A report of two cases with confirmation by immunoperoxidase studies on bone marrow sections

Abstract

Two cases of low-grade follicular lymphoma are presented in which evolution to a blastic phase with marrow and peripheral blood involvement occurred. One case was a follicular and diffuse mixed-cell lymphoma, while the second was a follicular and diffuse small cleaved-cell lymphoma. In both cases, at two and three years after initial presentation, a clinical picture resembling acute leukemia developed, with immature blastic-appearing infiltrates in the bone marrow and circulating blastic cells. Immunoperoxidase studies on fresh frozen sections of bone marrow in both cases confirmed the B-cell nature of the infiltrates and excluded the clinical impression of acute nonlymphocytic leukemia. The differential diagnosis of hematolymphoid infiltrates in the bone marrow in patients with follicular lymphoma is discussed.

Publication Title

American Journal of Clinical Pathology

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