Non-Hodgkin's lymphoma containing both B and T cell clones
Abstract
We describe a patient in whom two lymph node biopsies removed 18 months apart disclosed histologic and immunophenotypic evidence of a non-Hodgkin's lymphoma containing neoplastic lymphocytes of both B and T type. Analyses of immunoglobulin and T cell receptor genes confirmed the presence of separate B and T cell clones. In addition, immunogenotyping revealed the possibility of a second B cell clone within the patient's tumor. Development of a multiclonal lymphoma in this patient may relate to the carcinogenic effects of chemotherapy or to a predisposition for neoplastic transformation of lymphocytes due to a previously diagnosed autoimmune condition. Another possible explanation is that the lymphoma implies the existence of this patient of a transformed lymphocyte-committed stem cell that is capable of generating both B and T lineage clones.
Publication Title
Blood
Recommended Citation
Hu, E., Weiss, L., Warnke, R., & Sklar, J. (1987). Non-Hodgkin's lymphoma containing both B and T cell clones. Blood, 70 (1), 287-292. https://doi.org/10.1182/blood.v70.1.287.bloodjournal701287
