Peripheral blood hematopoietic stem cell mobilization and collection efficacy is not an independent prognostic factor for autologous stem cell transplantation

Authors

Shirong Wang, City of Hope National Med Center
Auayporn Nademanee, City of Hope National Med Center
Dajun Qian, City of Hope National Med Center
Andrew Dagis, City of Hope National Med Center
Hyun Soon Park, City of Hope National Med Center
Joy Fridey, City of Hope National Med Center
Eileen Smith, City of Hope National Med Center
David Snyder, City of Hope National Med Center
George Somlo, City of Hope National Med Center
Anthony Stein, City of Hope National Med Center
Joseph Rosenthal, City of Hope National Med Center
Peter Falk, City of Hope National Med Center
Neil Kogut, City of Hope National Med Center
Joycelynne Palmer, City of Hope National Med Center
Karl Gaal, City of Hope National Med Center
Young Kim, City of Hope National Med Center
Ravi Bhatia, City of Hope National Med Center
Shan Yuan, City of Hope National Med Center
Candace Kay, City of Hope National Med Center
Lawrence Weiss, City of Hope National Med Center
Stephen Forman, City of Hope National Med Center

Abstract

BACKGROUND: The successful mobilization and collection of hematopoietic stem cells are dependent on a number of clinical factors such as previous chemotherapy and disease stage. The aim of this retrospective study was to determine whether the effectiveness of mobilization and collection is an independent prognostic factor for autologous stem cell transplantation outcome. STUDY DESIGN AND METHODS: A total of 358 patients who received transplants from January 2003 to December 2004 (201 male and 157 female patients, ages from 2.7 to 77.3 years with median of 53 years of age) underwent autologous hematopoietic stem cell collection after mobilization with granulocyte-colony-stimulating factor (G-CSF) or G-CSF plus chemotherapy priming. This retrospective study included patients with diagnoses of acute myelogenous leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, and solid tumors. All patients underwent stem cell collection until a target or a minimum CD34+ cell dose was reached. Correlations were performed between stem cell mobilization and/or collection efficacy and transplantation outcomes. RESULTS: In general, both larger reinfused CD34+ cell dose and shorter number of days for the stem cell count to reach the minimum of 2 × 106 per kg CD34+ cells do not foster quicker engraftment. Reinfused CD34+ cell dose of less than 12 × 106 and number of days stem cell collection to reach this minimum CD34+ cell dose did not independently affect the overall survival (OS) or disease-free survival (DFS). CONCLUSION: The effectiveness of hematopoietic stem cell mobilization and collection as defined as number of days to reach a CD34+ cell dose of 2 × 106 per kg should not be used independently to forecast posttransplantation prognosis, engraftment, DFS, and OS. © 2007 American Association of Blood Banks.

Publication Title

Transfusion

Recommended Citation

Wang, S., Nademanee, A., Qian, D., Dagis, A., Park, H., Fridey, J., Smith, E., Snyder, D., Somlo, G., Stein, A., Rosenthal, J., Falk, P., Kogut, N., Palmer, J., Gaal, K., Kim, Y., Bhatia, R., Yuan, S., Kay, C., Weiss, L., & Forman, S. (2007). Peripheral blood hematopoietic stem cell mobilization and collection efficacy is not an independent prognostic factor for autologous stem cell transplantation. Transfusion, 47 (12), 2207-2216. https://doi.org/10.1111/j.1537-2995.2007.01448.x