The immunopathology of cutaneous lymphomas: Immunophenotypic and immunogenotypic characteristics

Abstract

Our understanding of the human immune system has been based in part on the detailed characterization of cellular differentiation with monoclonal antibody probes directed against a variety of T and B cell antigens (immunophenotyping). Recently, such methods have been complemented by the application of DNA hybridization probes that are used to detect rearrangements in T cell receptor and immunoglobulin genes, which occur during T and B cell differentiation, respectively (immunogenotyping). Together these techniques afford an effective means of studying the differentiation and clonality of both inflammatory and neoplastic lymphoid lesions, including those that occur within the skin.

Publication Title

Seminars in Dermatology

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