Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia

Authors

Laila Elsherif, University of Tennessee Health Science Center
Praghalathan Kanthakumar, University of Tennessee Health Science Center
Jeremiah Afolabi, University of Tennessee Health Science Center
Ashley F. Stratton, University of Tennessee Health Science Center
Ugochi Ogu, University of Tennessee Health Science Center
Marquita Nelson, University of Tennessee Health Science Center
Ayesha Mukhopadhyay, University of Memphis
Matthew P. Smeltzer, University of Memphis
Adebowale Adebiyi, University of Tennessee Health Science Center
Kenneth I. Ataga, University of Tennessee Health Science Center

Abstract

We explored the association of novel urinary biomarkers with albumin-creatinine ratio (ACR) in adults with sickle cell anaemia. Of 37 participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin (p = 0.002), retinol-binding protein 4 (p = 0.008), alpha-1 microglobulin (p = 0.002) and angiotensinogen (p = 0.006) were significantly higher in participants with PA than in those without PA. Although univariate analysis showed significant associations between both alpha-1 microglobulin (p = 0.035) and angiotensinogen (p = 0.0021) with ACR, only angiotensinogen was associated with ACR in multivariable analysis (p = 0.04). Our results suggest that urinary angiotensinogen may identify sickle cell anaemia patients at risk for kidney disease.

Publication Title

British Journal of Haematology

Recommended Citation

Elsherif, L., Kanthakumar, P., Afolabi, J., Stratton, A., Ogu, U., Nelson, M., Mukhopadhyay, A., Smeltzer, M., Adebiyi, A., & Ataga, K. (2023). Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia. British Journal of Haematology, 202 (3), 669-673. https://doi.org/10.1111/bjh.18862