Sphingosine 1-phosphate and lysophosphatidic acid receptors: Agonist and antagonist binding and progress toward development of receptor-specific ligands

Authors

Abby L. Parrill, University of Memphis
Vineet M. Sardar, University of Memphis
Hongbin Yuan, University of MemphisFollow

Abstract

Sphingosine 1-phosphate and lysophosphatidic acid are two phospholipid growth factors whose importance in physiology and pathophysiology is becoming more and more apparent. Structure-activity relationships for agonism and antagonism at the thirteen known cell-surface and one intracellular receptor are described. Particular emphasis is placed on ligands having different selectivity than the parent molecules. Structural insights regarding agonist and antagonist recognition by the receptors from both computational modeling studies and crystallography are also discussed. © 2004 Elsevier Ltd. All rights reserved.

Publication Title

Seminars in Cell and Developmental Biology

Recommended Citation

Parrill, A., Sardar, V., & Yuan, H. (2004). Sphingosine 1-phosphate and lysophosphatidic acid receptors: Agonist and antagonist binding and progress toward development of receptor-specific ligands. Seminars in Cell and Developmental Biology, 15 (5), 467-476. https://doi.org/10.1016/j.semcdb.2004.05.006