Synthesis of methoxy and hydroxy containing tetralones: Versatile intermediates for the preparation of biologically relevant molecules
Abstract
The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihyroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest. © 2003 Elsevier Science Ltd. All rights reserved.
Publication Title
Tetrahedron Letters
Recommended Citation
Ghatak, A., Dorsey, J., Garner, C., & Pinney, K. (2003). Synthesis of methoxy and hydroxy containing tetralones: Versatile intermediates for the preparation of biologically relevant molecules. Tetrahedron Letters, 44 (21), 4145-4148. https://doi.org/10.1016/S0040-4039(03)00715-9
