Polymer-encapsulated phosphor particles for in vivo phosphor luminescence applications

Abstract

Phosphor thermometry is a highly sensitive, rapid, and portable thermal sensing technique that offers advantages over traditional contact-based thermometry techniques. Phosphor particles would however require an encapsulation medium that is biocompatible and yet optically transparent to permit optical access to the embedded phosphor particles. Here, phosphor-doped silicone implants with varying concentrations were prepared and tested in a rat model. Results indicate that such phosphor-doped polymeric implants are stable, produce a detectable signal, and demonstrate the feasibility of phosphor thermometry as a noninvasive remote thermal sensing technique for in vivo applications. Also, encapsulation in silicone did not lead to significant attenuation of the incoming signal.

Publication Title

International Journal of Polymeric Materials and Polymeric Biomaterials

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