Title

Essential Tremor: Animal Models

Abstract

Animal models of essential tremor with variable degrees of face, predictive, and etiological validity have been generated with neurotoxins, pharmacological agents, and genetic engineering. The harmaline tremor model which is based on activation of the climbing fiber pathway from the inferior olive to cerebellar Purkinje cells has demonstrated utility as a therapeutic screening tool.

Publication Title

Encyclopedia of Movement Disorders

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