Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat
Abstract
Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with the human sequence. Northern blot analysis detects a single transcript of approximately 1.5 kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No mutations were identified in the coding region of the gene in the genetically dystonic (dt) rat. © 2002 Elsevier Science B.V. All rights reserved.
Publication Title
Molecular Brain Research
Recommended Citation
Ziefer, P., Leung, J., Razzano, T., Shalish, C., LeDoux, M., Lorden, J., Ozelius, L., & Breakefield, X. (2002). Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat. Molecular Brain Research, 101 (1-2), 132-135. https://doi.org/10.1016/S0169-328X(02)00176-6
