The Collaborative Cross, a community resource for the genetic analysis of complex traits

Authors

Gary A. Churchill, Jackson Laboratory
David C. Airey, Vanderbilt University
Hooman Allayee, Keck School of Medicine of USC
Joe M. Angel, Virginia Harris Cockrell Cancer Research Center at The University of Texas MD Anderson Cancer Center
Alan D. Attie, University of Wisconsin-Madison
Jackson Beatty, University of California, Los Angeles
Willam D. Beavis, National Center for Genome Resources
John K. Belknap, Portland VA Medical CenterFollow

Abstract

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

Publication Title

Nature Genetics

Recommended Citation

Churchill, G., Airey, D., Allayee, H., Angel, J., Attie, A., Beatty, J., Beavis, W., & Belknap, J. (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics, 36 (11), 1133-1137. https://doi.org/10.1038/ng1104-1133