Biological pathways impacting cancer survival: Exercise as a countermeasure for the development and progression of cachexia
Abstract
This chapter will illustrate the signaling pathways that are influenced by exercise that could impact cancer patient survival as it relates to the treatment and prevention of cachexia. Cancer cachexia involves an unintentional body weight loss, which includes muscle and fat mass loss. Cachexia is most prevalent with cancers of the colon, lung and pancreas, and the development of cachexia coincides with increased patient morbidity, mortality, and a reduction in quality of life. This chapter will focus on the ability of exercise to improve an environment that involves suppressed anabolic signaling pathways, activated catabolic signaling pathways, and disrupted metabolic signaling. These changes will be considered in terms of the impact of processes involved in local and systemic metabolism. Exercise will be examined in respect to both acute changes and chronic exercise adaptations. Additionally, the complexity of this biological response as it pertains to the intensity and duration of exercise will be highlighted.
Publication Title
Exercise, Energy Balance, and Cancer
Recommended Citation
Carson, J., & Puppa, M. (2013). Biological pathways impacting cancer survival: Exercise as a countermeasure for the development and progression of cachexia. Exercise, Energy Balance, and Cancer, 59-81. https://doi.org/10.1007/978-1-4614-4493-0_5
