Identifier

229

Date

2023

Document Type

Honors Thesis

Degree Name

Bachelor of Science in Biomedical Engineering

Major

Biomedical Engineering

Committee Chair

Joel Bumgardner

Abstract

Guided bone regeneration (GBR) is a process used to enhance bone growth and treat alveolar bone loss when insufficient bone volume is present. GBR uses membranes to prevent soft tissue infiltration into areas of new bone growth, and in previous studies, GBE membranes have been used for local drug delivery to promote wound healing. Macrophages are immune cells that polarize from an M1 pro-inflammatory phenotype to an M2 pro-healing phenotype as wound healing progresses. Previous research has identified significant potential in the use of raspberry ketone (RK), a compound of red raspberry, in the modulation of macrophage polarization towards the M2, pro-healing, phenotype. This study analyzed the effects of raspberry ketone on pro-inflammatory and anti-inflammatory cytokine production in-vitro using RAW 264.7 cells. Twenty cytokines were measured, providing insight into inflammatory mediators that are present in RAW 264.7 culture models as well as the effects of RK on cytokine production.

Comments

Undergraduate Honor's Thesis

Library Comment

Honors thesis originally submitted to the Local University of Memphis Honor’s Thesis Repository.

Notes

Data is provided by the student.

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