Identifier

237

Date

2024

Document Type

Honors Thesis

Degree Name

Bachelor of Science in Biomedical Engineering

Major

Biomedical Engineering

Committee Chair

Timothy Brewster

Abstract

This study focuses on the optimization of a synthetic pathway used to synthesize traceless tether ligands in the Tripy family. The formation of new carbon-carbon bonds with a high degree of regioselectivity is imperative for synthetic organic chemistry, where reactions such as cross-coupling allow to form carbon-carbon bonds by using transition metal organometallic reagents. Traditionally, it involves a leaving group, and the reaction only occurs at the site of the leaving group. Where the goal of this project was to determine a way to get the same level of regioselectivity as is obtained in cross-coupling reactions without the need for a leaving group. The synthesis and testing of 4-azidomethyl-phenol, 4-pyridyl-triazole-phenol (4-TriPy), and the attachment and deprotection of a protected directing group aldehyde to 4-TriPy were analyzed throughout this study and found to be reliable and reproductible with acceptable yield.

Comments

Undergraduate Honor's Thesis

Library Comment

Honors thesis originally submitted to the Local University of Memphis Honor’s Thesis Repository.

Notes

Data is provided by the student.

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