Cerebellar Modulation of Striatal Dopaminergic Transmission in Fragile-X Mice: Implications for Autism Research

Identifier

66

Author

Danielle Hope Thomas

Date

2016

Document Type

Honors Thesis

Degree Name

Bachelor of Arts

Major

Psychology

Concentration

Behavioral Neuroscience

Committee Member

Charles Blaha

Committee Member

Randy Floyd

Abstract

The objective of this research was to use fixed-potential amperometry (FPA) and electrical stimulation as an independent variable to measure and quantify dopaminergic transmission in the most lateral aspect of the striatum elicited by the dentate nucleus (DN) in both Fmr1 wildtype and Fmr1 mutant, or knockout (KO), mice to determine the differences, if any, in dopaminergic transmission. The aim of this research was to contribute to understanding if and how dopaminergic transmission in this pathway contributes to motor deficits associated with Autism spectrum disorders (ASD). Results from a one-way ANOVA showed no significant difference in average stimulation-evoked dopaminergic transmission in the striatum between the Fmr1 control and mutant mice groups, p = .15. Results are discussed, as well as the implications this study has on future research on cerebellum modulated dopaminergic transmission to the striatum in ASD.

Comments

Undergraduate Honor's Thesis

Library Comment

Honors thesis originally submitted to the Local University of Memphis Honor’s Thesis Repository.

Notes

Data is provided by the student.

Recommended Citation

Thomas, Danielle Hope, "Cerebellar Modulation of Striatal Dopaminergic Transmission in Fragile-X Mice: Implications for Autism Research" (2016). Honors Theses. 39.
https://digitalcommons.memphis.edu/honors_theses/39