Identifier

117

Date

2018

Document Type

Honors Thesis

Degree Name

Bachelor of Science in Biomedical Engineering

Major

Biomedical Engineering

Committee Member

Joel D. Bumgardner

Abstract

Chitosan has been investigated as a coating for musculoskeletal implants due to its osteoconductive and local drug delivery properties. Since chitosan is dissolved in dilute organic acid, the residual acid components must be removed post coating, which is typically done using alkali and/or ethanol treatments. Neutralization affects coating surface chemistry, adhesion, swelling, and other properties. The aim of this study is to compare the effects of NaOH neutralization versus phosphate buffer neutralization on solution cast coatings on commercially pure titanium. Properties evaluated were contact angle, swelling/drug release, coating adhesion, bone cell attachment, bone cell proliferation, and bone cell mineralization. Results show that phosphate buffer neutralization produces coatings with properties that are more favorable for implant device applications.

Comments

Undergraduate Honor's Thesis

Library Comment

Honors thesis originally submitted to the Local University of Memphis Honor’s Thesis Repository.

Notes

Data is provided by the student.

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