Metachronous T-Lymphoblastic Lymphoma and Burkitt Lymphoma in a Child With Constitutional Mismatch Repair Deficiency Syndrome
Abstract
Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with a high risk of developing early-onset malignancies of the blood, brain, and intestinal tract. We present the case of a patient with T-lymphoblastic lymphoma at the age of 3 years, followed by Burkitt lymphoma 10 years later. This patient also exhibited numerous nonmalignant findings including café au lait spots, lipomas, bilateral renal nodules, a nonossifying fibroma, multiple colonic adenomas, and a rapidly enlarging pilomatrixoma. The spectrum of malignant and nonmalignant neoplasms in this patient highlights the remarkable diversity, and early onset, of lesions seen in children with CMMRD.
Publication Title
Pediatric blood & cancer
Recommended Citation
Alexander, Thomas B.; McGee, Rose B.; Kaye, Erica C.; McCarville, Mary Beth; Choi, John K.; Cavender, Cary P.; Nichols, Kim E.; and Sandlund, John T., "Metachronous T-Lymphoblastic Lymphoma and Burkitt Lymphoma in a Child With Constitutional Mismatch Repair Deficiency Syndrome" (2016). Loewenberg College of Nursing Faculty Publications. 102.
https://digitalcommons.memphis.edu/lcon-facpubs/102
