Update on neuroblastoma

Authors

Erika A. Newman, C.S Mott Children's Hospital, The University of Michigan Medicine, Ann Arbor, MI. Electronic address: eanewman@med.umich.edu.
Shahab Abdessalam, Children's Hospital and Medical Center Omaha, Omaha, NE.
Jennifer H. Aldrink, Nationwide Children's Hospital, Columbus, OH.
Mary Austin, Memorial Hermann Texas Medical Center, Houston, TX.
Todd E. Heaton, Memorial Sloan Kettering Cancer Center, NY, New York.
Jennifer Bruny, Children's Hospital of Colorado, Aurora, CO.
Peter Ehrlich, C.S Mott Children's Hospital, The University of Michigan Medicine, Ann Arbor, MI.
Roshni Dasgupta, Cincinnati Children's Hospital, Cincinnati, OH.
Reto M. Baertschiger, Children's Hospital at Dartmouth, Lebanon, NH.
Timothy B. Lautz, Ann & Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL.
Daniel S. Rhee, Johns Hopkins Hospital, Baltimore, MD.
Max R. Langham, University of Tennessee Health Science Center and St. Jude Children's Research Hospital, Memphis, TN.
Marcus M. Malek, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Rebecka L. Meyers, Primary Children's Hospital, University of Utah, Salt Lake City, UT.
Jaimie D. Nathan, Cincinnati Children's Hospital, Cincinnati, OH.
Brent R. Weil, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA.
Stephanie Polites, Cincinnati Children's Hospital, Cincinnati, OH.
Mary Beth Madonna, Ann & Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL.

Abstract

Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. TYPE OF STUDY: Review article. LEVEL OF EVIDENCE: Level II.

Publication Title

Journal of pediatric surgery

Recommended Citation

Newman, Erika A.; Abdessalam, Shahab; Aldrink, Jennifer H.; Austin, Mary; Heaton, Todd E.; Bruny, Jennifer; Ehrlich, Peter; Dasgupta, Roshni; Baertschiger, Reto M.; Lautz, Timothy B.; Rhee, Daniel S.; Langham, Max R.; Malek, Marcus M.; Meyers, Rebecka L.; Nathan, Jaimie D.; Weil, Brent R.; Polites, Stephanie; and Madonna, Mary Beth, "Update on neuroblastoma" (2019). Loewenberg College of Nursing Faculty Publications. 165.
https://digitalcommons.memphis.edu/lcon-facpubs/165