Current and coming challenges in the management of the survivorship population

Authors

Eric J. Chow, Division of Clinical Research and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington, Seattle, Washington. Electronic address: ericchow@uw.edu.
Kirsten K. Ness, Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gregory T. Armstrong, Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.Follow
Nickhill Bhakta, Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Jennifer M. Yeh, Division of General Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.Follow
Smita Bhatia, Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.Follow
Wendy Landier, Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.
Louis S. Constine, Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York.
Melissa M. Hudson, Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Paul C. Nathan, Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Abstract

With the widespread adoption of multimodality treatment, 5-year survival of children diagnosed with cancer has improved dramatically in the past several decades from approximately 60% in 1970 to greater than 85% currently. As a result, there are an estimated nearly half a million long-term survivors of childhood cancer living in the United States today. However, survivors have, on average, significantly greater serious medical and psychosocial late effects compared with the general population. In this review, we will discuss the current epidemiology of childhood cancer survivorship, including new methods to estimate the burden of late effects and genetic susceptibility toward late effects. We will also review the development of surveillance guidelines for childhood cancer survivors and early toxicity signals from novel agents now being tested and used increasingly to treat pediatric and adult cancers. We conclude with an overview of current models of survivorship care and areas for future research.

Publication Title

Seminars in oncology

Recommended Citation

Chow, Eric J.; Ness, Kirsten K.; Armstrong, Gregory T.; Bhakta, Nickhill; Yeh, Jennifer M.; Bhatia, Smita; Landier, Wendy; Constine, Louis S.; Hudson, Melissa M.; and Nathan, Paul C., "Current and coming challenges in the management of the survivorship population" (2020). Loewenberg College of Nursing Faculty Publications. 42.
https://digitalcommons.memphis.edu/lcon-facpubs/42