Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation

Rachel Phelan, CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. rphelan@mcw.edu.
Annie Im, University of Pittsburgh/UPMC Hillman Cancer Center, Pittsburgh, PA, USA.Follow
Rebecca L. Hunter, Division of Hematology, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Yoshihiro Inamoto, Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Maria Teresa Lupo-Stanghellini, Hematology and Bone Marrow Transplantation Unit, IRCC San Raffaele Scientific Institute, Milano, Italy.
Alicia Rovo, Department of Hematology and Central Hematology Laboratory, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
Sherif M. Badawy, Division of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.Follow
Linda Burns, CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Hesham Eissa, Department of Pediatrics, Center for Cancer and Blood Disorders, University of Colorado School of Medicine, Aurora, CO, USA.
Hemant S. Murthy, Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL, USA.
Pinki Prasad, Louisiana State University Health Sciences Center/Children's Hospital of New Orleans, Department of Pediatrics, New Orleans, LA, USA.
Akshay Sharma, Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
Elizabeth Suelzer, Medical College of Wisconsin, Milwaukee, WI, USA.
Vaibhav Agrawal, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.Follow
Mahmoud Aljurf, Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia.
Karen Baker, Duke University Medical Center, Durham, NC, USA.
Grzegorz W. Basak, University Clinical Centre, Medical University of Warsaw, Warsaw, Poland.
David Buchbinder, Division of Pediatric Hematology, Children's Hospital of Orange County, Orange, CA, USA.Follow
Zachariah DeFilipp, Hematopoietic Cell Transplant and Cellular Therapy Program, Massachusetts General Hospital, Boston, MA, USA.Follow
Lana Desnica Grkovic, University Hospital Centre Zagreb, Zagreb, Croatia.
Ajoy Dias, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Hermann Einsele, Universitätsklinikum Würzburg, Department of Internal Medicine II, Würzburg, Germany.
Michael L. Eisenberg, Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Narendranath Epperla, Division of Hematology, Department of Medicine, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.
Nosha Farhadfar, Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, FL, USA.Follow
Arthur Flatau, Association of Cancer Online Resources, Association of Cancer Online Resources, Austin, TX, USA.Follow
Robert Peter Gale, Haematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.Follow
Hildegard Greinix, Medical University Graz, Division of Hematology, Graz, Austria.
Betty K. Hamilton, Blood & Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.Follow
Shahrukh Hashmi, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Peiman Hematti, Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin, Madison, WI, USA.
Kareem Jamani, Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.Follow
Dipnarine Maharaj, South Florida Bone Marrow Stem Cell Transplant Institute, Boynton Beach, FL, USA.

Abstract

Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.

Publication Title

Bone marrow transplantation

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