Electronic Theses and Dissertations

Identifier

2601

Date

2016

Document Type

Thesis

Degree Name

Master of Science

Major

Health and Sport Science

Concentration

Exercise and Sport Science

Committee Chair

Chad D Touchberry

Committee Member

Richard J Bloomer

Committee Member

Helen J Sable

Abstract

Basal heat shock protein (HSP) expression and the HSP response to stress in skeletal muscle are reduced during diabetes. However, it remains unknown if HSP expression is impaired during the pre-diabetic state. Therefore, we determined if basal level or exercise-induced elevations in HSP expression were attenuated by diet-induced insulin resistance (IR). Twenty-eight male Long-Evans rats (n=7/group) were subjected to 12 weeks of dietary (Western diet [WD] versus purified vegan diet [PD]) and physical activity (exercise [25mmin-1 for 35 minday-1, 3x/week] versus sedentary) intervention. We hypothesized that basal HSP expression would be reduced in animals with IR. WD groups developed IR independent of exercise. Exercise groups displayed a uniform increase in HSP expression independent of IR (p<0.05). There was no association between HSP expression and IR (r2=0.00). Our data indicate that HSP expression is maintained during a state of IR and the HSP response may be protected by preemptive exercise treatment.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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