Date of Award
Master of Science
The phase behavior of lipid membrane next to solid substrates isinvestigated numerically using molecular dynamics simulations of a coarse- grained implicit-solvent model. We particularly investigated the effect of the strength of the adhesion of the lipids on the substrate on the gel-fluid phase transition. The behavior of the proximal leaflet of the lipid bilayer can be dramatically different from that of the distal leaflet, particularly for large adhesion strengths. In the gel phase, the lipids of the proximal leaflet are uniformly in the gel phase while the lipids of the distal leaflet are spatially distributed in coexisting gel and fluid domains. We have shown that the difference in the behavior of the two leaflets is due to the difference in their lipid densities. The different lipid densities are the result of enhanced lipid translocation from the distal leaflet to the proximal leaflet due to the attractive substrate.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Poursoroush, Asma, "The Effects of Solid Substrates on Thermodynamics of Lipid Membranes" (2016). Electronic Theses and Dissertations. 1483.