Date of Award
Master of Science
Health and Sport Science
Exercise, Sport & Movement Sci
Marie van der Merwe
Background: Various forms of fasting can result in improvements in insulin sensitivity. Objective: Compare the effects of various fasting models on measures of insulin sensitivity in young male C57BL/6 mice. Methods: 60 mice were assigned to the following groups: HF, CHOW, SWITCH, DF, CR, TRF, and ADF for 8 weeks, following a 6 week lead-in period of ad libitum HF consumption. Fasting blood glucose (mg/dL) and insulin (ng/mL) were measured and HOMA-IR, determined. Glucose tolerance tests were performed to determine glucose clearance pre- and post-intervention. Results: Compared to the HF ad libitum group, all groups displayed significantly lower fasting glucose, insulin, and HOMA-IR, as well as improved glucose tolerance. Additionally, ADF displayed the lowest fasting blood glucose and glucose AUC. Conclusion: All investigated fasting protocols may improve fasting glucose, insulin, and HOMA-IR. ADF may allow for ideal fasting blood glucose and clearance of glucose loads following a glucose challenge.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Caldwell, Jade Leanna, "Comparison of Dietary and Caloric Restriction Models on Insulin Sensitivity in Young Mice" (2018). Electronic Theses and Dissertations. 1800.