Date of Award
Master of Science
Marie van der Merwe
Food intake and exercise are considered modulators of the immune system. Time-restricted feeding (TRF) protocols have been shown to reduce inflammation and alter cytokine response. The objective of this study was to determine if TRF would alter immune parameters in response to exercise. Thirty-six C57BL/6 mice were divided into three groups; control had access to food ad libitum, TRF groups had access for six hours either immediately after running (TRF-imm) or five hours after running (TRF-del). Mice ran on the treadmill for eight weeks. Overall, TRF-imm gained less weight than control. B-hydroxybutyrate (BHB) was higher in fasted groups but running induced BHB in all groups. Exercise reduced lymphocytes levels and increased granulocytes in all groups. Cytokine IL-6 was low, but post-exercise it was increased in all groups; however, the response was reduced in TRF groups. Our data suggest that TRF does not alter immune composition but reduces exercise-induced IL-6 levels.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Faietti, Martina, "Impact of Time-restricted Feeding and Exercise on Immunity in Male C57BL/6 Mice" (2020). Electronic Theses and Dissertations. 2069.