Electronic Theses and Dissertations

Date

2023

Document Type

Dissertation

Degree Name

Doctor of Philosophy

Department

Chemistry

Committee Chair

Charles Garner

Committee Member

Timothy Brewster

Committee Member

Michael A Brown

Committee Member

Tomoko Fujiwara

Committee Member

Xuan Zhao

Abstract

The discovery of new catalysts and reactions is an important field in chemical synthesis. Typical catalyst screening methods require two steps: reaction and analysis. In this work, both of these steps have been successfully combined using a gas chromatograph (GC) with an inlet injection port liner that has been intentionally “contaminated” with a catalyst. This allows the instrument to perform as a microreactor while continuing to function as an incredibly powerful tool for identification of reaction components. It was observed that GC retention times were highly reproducible even for compounds formed directly in the inlet. This method has the potential to rapidly screen a large number of substrates and catalysts. Newly-discovered reactions can therefore be studied preparatively through the unique use of a packed-column GC equipped with a nondestructive detector as a fixed bed flow reactor. The products of any given reaction can then be collected for further identification as necessary. Further work was conducted to apply these reactions from these specific conditions and transition them to solution-phase reactions.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to ProQuest.

Notes

Open Access

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