Chitosan: Potential use as a bioactive coating for orthopaedic and craniofacial/dental implants
Abstract
Chitosan is a biopolymer that exhibits osteoconductive, enhanced wound healing and antimicrobial properties which make it attractive for use as a bioactive coating to improve osseointegration of orthopaedic and craniofacial implant devices. Coatings made from 91.2% de-acetylated chitosan were chemically bonded to titanium coupons via silane-glutaraldehyde molecules. The bond strength of the coatings was evaluated in mechanical tensile tests, and their dissolution and cytocompatibility were evaluated in vitro using cell-culture medium and UMR 106 osteoblastic cells, respectively. The results showed that the chitosan coatings were chemically bonded to the titanium substrate and that the bond strengths (1.5-1.8 MPa) were not affected by gas sterilization. However, the chitosan bond strengths were less than those reported for calcium-phosphate coatings. The gas-sterilized coatings exhibited little dissolution over 8 weeks in cell-culture solution, and the attachment and growth of the UMR 106 osteoblast cells was greater on the chitosan-coated samples than on the uncoated titanium. These results indicated that chitosan has the potential to be used as a biocompatible, bioactive coating for orthopaedic and craniofacial implant devices.
Publication Title
Journal of Biomaterials Science, Polymer Edition
Recommended Citation
Bumgardner, J., Wiser, R., Gerard, P., Bergin, P., Chestnutt, B., Marini, M., Ramsey, V., Elder, S., & Gilbert, J. (2003). Chitosan: Potential use as a bioactive coating for orthopaedic and craniofacial/dental implants. Journal of Biomaterials Science, Polymer Edition, 14 (5), 423-438. https://doi.org/10.1163/156856203766652048
