A mild and regioselective method for α-bromination of β-keto esters and 1,3-diketones using bromodimethylsulfonium bromide (BDMS)
Abstract
Bromodimethylsulfonium bromide has been found to be an effective and regioselective reagent for α-monobromination of β-keto esters and 1,3-diketones. A wide variety of β-keto esters and 1,3-diketones undergo chemoselective α-monobromination with excellent yields at 0-5 °C or room temperature. The notable advantages of this protocol are no need of chromatographic separation, use of less hazardous reagent than molecular bromine, and no added base, Lewis acid, or other catalyst. © 2006 American Chemical Society.
Publication Title
Journal of Organic Chemistry
Recommended Citation
Khan, A., Ali, M., Goswami, P., & Choudhury, L. (2006). A mild and regioselective method for α-bromination of β-keto esters and 1,3-diketones using bromodimethylsulfonium bromide (BDMS). Journal of Organic Chemistry (23), 8961-8963. https://doi.org/10.1021/jo061501r
