Cis-2-Decenoic Acid Interacts with Bacterial Cell Membranes to Potentiate Additive and Synergistic Responses Against Biofilm in Orthopaedic Pathogens

Identifier

83

Author

Elysia Anne Masters

Date

2016

Document Type

Honors Thesis

Degree Name

Bachelor of Science in Biomedical Engineering

Major

Biomedical Engineering

Committee Chair

Amber Jennings

Abstract

Musculoskeletal infection is a major risk in all wounds, especially orthopaedic procedures such as implants or bone grafts. Morbidity due to implant-associated infections has increased and the need for therapeutic strategies to prevent them is growing. Biofilm dispersal agen, cis-2-decenoic acid (C2DA) may be used in conjunction with a variety of antibiotics to potentiate syngeristic, additive and antagonistic responses against orthopaedic pathogens. Our studies have shown that this response can be predicted based on the antibiotic's mechanism of action. Evidence shows that synergism may be caused by an increase in membrane permeability due to the incorporation of fatty acid C2DA, thus allowing increased amounts of antibiotic to enter the cell and exert its effects.

Comments

Undergraduate Honor's Thesis

Library Comment

Honors thesis originally submitted to the Local University of Memphis Honor’s Thesis Repository.

Notes

Data is provided by the student.

Recommended Citation

Masters, Elysia Anne, "Cis-2-Decenoic Acid Interacts with Bacterial Cell Membranes to Potentiate Additive and Synergistic Responses Against Biofilm in Orthopaedic Pathogens" (2016). Honors Theses. 47.
https://digitalcommons.memphis.edu/honors_theses/47